Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201315 | 0.87 | TGFBR1 (0.70) | TGFBR1ROCK2CLK4ROCK1CLK2 | |
| SCHEMBL3574349 | 0.82 | TGFBR1 (0.69) | TGFBR1ROCK2CLK4ROCK1CLK2 | |
| SCHEMBL29395013 | 0.82 | TGFBR1 (0.71) | TGFBR1ROCK2CLK4LMNAROCK1 | |
| SCHEMBL13154697 | 0.82 | TGFBR1 (0.71) | TGFBR1ROCK2CLK4LMNAROCK1 | |
| SCHEMBL11920094 | 0.82 | ROCK2 (0.75) | TGFBR1ROCK2CLK4LMNAROCK1 | |
| SCHEMBL3586914 | 0.81 | TGFBR1 (0.71) | TGFBR1ROCK2CLK4ALDH1A1LMNA | |
| SCHEMBL11920216 | 0.81 | ROCK2 (0.69) | TGFBR1ROCK2CLK4ROCK1CLK2 | |
| SCHEMBL22201667 | 0.81 | ABCG2 (0.67) | CLK4ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL3578259 | 0.81 | ROCK2 (0.78) | TGFBR1ROCK2CLK4ALDH1A1LMNA | |
| SCHEMBL3585107 | 0.81 | TGFBR1 (0.69) | TGFBR1ROCK2CLK4ROCK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |