SCHEMBL2220185

SCHEMBL2220185

COc1nc(Cl)nc(Nc2ccc(C=Cc3ccc(Nc4nc(OC)nc(N5CCOCC5)n4)cc3S(=O)(=O)O)c(S(=O)(=O)O)c2)n1.[Na].[Na]

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
PTGS2 P35354 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
TSHR P16473 1/20 0.45
CA12 O43570 3/20 0.44
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA9 Q16790 3/20 0.44
MAPK1 P28482 3/20 0.44
MAPT P10636 3/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ITGB1 P05556 1/20 0.42
ITGA4 P13612 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17328820 0.99 HSD17B10 (0.48) USP2HSD17B10MEN1KMT2APTGS2
SCHEMBL14390759 0.94 HSD17B10 (0.52) USP2HSD17B10MEN1KMT2APTGS2
SCHEMBL2222266 0.90 PTGS2 (0.52) MEN1KMT2APTGS2TDP1SMN1; SMN2
SCHEMBL2220181 0.90 USP2 (0.47) USP2HSD17B10MEN1KMT2APTGS2
SCHEMBL12994676 0.90 HSD17B10 (0.49) USP2HSD17B10MEN1KMT2APTGS2
SCHEMBL2202879 0.90 SMN1; SMN2 (0.53) HSD17B10MEN1KMT2APTGS2TDP1
SCHEMBL14391125 0.90 SMN1; SMN2 (0.53) HSD17B10MEN1KMT2APTGS2TDP1
SCHEMBL11728864 0.89 PTGS2 (0.52) HSD17B10MEN1KMT2APTGS2TDP1
SCHEMBL3927919 0.89 PTGS2 (0.52) HSD17B10MEN1KMT2APTGS2TDP1
SCHEMBL14609197 0.88 MEN1 (0.47) USP2HSD17B10MEN1KMT2APTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2722190-A1 Optimized undercoat for thermal recording material Ricoh Industrie France SAS (FR) 2014-04-23 EP disclosed
US-8546300-B2 Thermosensitive recording material and image recording method RICOH COMPANY, LTD. (JP) 2013-10-01 US disclosed
US-20110177941-A1 THERMOSENSITIVE RECORDING MATERIAL AND IMAGE RECORDING METHOD RICOH COMPANY, LTD. (JP) 2011-07-21 US disclosed