Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22207107 | 0.80 | FPR2 (0.50) | SMN1; SMN2TP53NPC1RAB9AHDAC6 | |
| SCHEMBL12124304 | 0.80 | SMYD3 (0.47) | SMN1; SMN2LMNAIKBKBCHUKNPC1 | |
| SCHEMBL19951035 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK10LMNAIKBKBCHUK | |
| SCHEMBL15296863 | 0.79 | SMYD3 (0.50) | SMN1; SMN2LMNATP53IKBKBCHUK | |
| SCHEMBL17065934 | 0.78 | ULK1 (0.44) | SMN1; SMN2MAPK10LMNAHDAC6HDAC1 | |
| SCHEMBL15550220 | 0.75 | LMNA (0.46) | SMN1; SMN2MAPK10LMNANPC1RAB9A | |
| SCHEMBL6288006 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK10LMNANPC1RAB9A | |
| SCHEMBL1808824 | 0.74 | — | — | |
| SCHEMBL23617261 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPK10LMNANPC1RAB9A | |
| SCHEMBL2605695 | 0.72 | HDAC6 (0.60) | NPC1HDAC6HDAC1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114014854-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-113999224-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-114014854-A | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-113999224-A | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-01 | — | — | CN | disclosed |
| EP-3909951-A1 | DIHYDROISOQUINOLINE COMPOUND | Suzhou Ark Biopharmaceutical Co., Ltd (CN) | 2021-11-17 | — | — | EP | disclosed |
| WO-2020143604-A1 | DIHYDROISOQUINOLINE COMPOUND | 苏州爱科百发生物医药技术有限公司 | 2020-07-16 | — | — | WO | disclosed |
| WO-2020143604-A1 | DIHYDROISOQUINOLINE COMPOUND | 苏州爱科百发生物医药技术有限公司 | 2020-07-16 | — | — | WO | disclosed |
| CN-111410653-A | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2020-07-14 | — | — | CN | disclosed |