Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12130341 | 0.72 | SMN1; SMN2 (0.39) | TSHRALDH1A1KDM4ETP53TDP1 | |
| SCHEMBL27341809 | 0.71 | DPP4 (0.39) | DPP4TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL22224593 | 0.70 | BRPF1 (0.39) | TSHRALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL31667532 | 0.68 | BRPF1 (0.38) | TSHRALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL22207153 | 0.68 | BRPF1 (0.41) | TSHRALDH1A1KDM4EHSD17B10CA12 | |
| SCHEMBL31667098 | 0.68 | BRPF1 (0.34) | ALDH1A1CA12BRD4BRPF1CA9 | |
| SCHEMBL24850345 | 0.67 | ALDH1A1 (0.39) | TSHRALDH1A1HSD17B10L3MBTL1KMT2A | |
| SCHEMBL1431321 | 0.65 | HTT (0.53) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL22224637 | 0.65 | BRPF1 (0.35) | ALDH1A1KDM4ECA12BRD4BRPF1 | |
| SCHEMBL31666972 | 0.65 | SMN1; SMN2 (0.36) | ALDH1A1KDM4ETDP1CA12BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3908579-B1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH INC (US) | 2023-12-27 | — | — | EP | disclosed |
| US-20220089568-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. | 2022-03-24 | — | — | US | disclosed |
| EP-3908579-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| CN-113574054-A | Dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2021-10-29 | — | — | CN | disclosed |
| WO-2020144638-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2020144638-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2020-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089568-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, DLD, DPYD | DPP4 3014/4885TSHR 3632/4885ALDH1A1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.