⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18446 | 0.84 | ALDH1A1 (0.53) | — | |
| SCHEMBL23234042 | 0.80 | — | — | |
| SCHEMBL2948744 | 0.79 | ALDH1A1 (0.48) | — | |
| SCHEMBL125810 | 0.77 | — | — | |
| SCHEMBL16811766 | 0.77 | ALDH1A1 (0.50) | — | |
| SCHEMBL27767863 | 0.77 | — | — | |
| SCHEMBL733363 | 0.76 | — | — | |
| SCHEMBL2945943 | 0.75 | GAA (0.46) | — | |
| SCHEMBL28689574 | 0.75 | — | — | |
| SCHEMBL23212269 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570612-B2 | Substituted nitrogen heterocyclic compound and anesthetic effect thereof | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2026-03-10 | — | — | US | disclosed |
| US-20230026724-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2023-01-26 | — | — | US | disclosed |
| CN-115197046-A | Halogenation method of unsaturated hydrocarbon | 华南理工大学 | 2022-10-18 | — | — | CN | disclosed |
| EP-4043440-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2022-08-17 | — | — | EP | disclosed |
| CN-114262301-A | Small molecule antagonist targeting EP4 receptor and application thereof in osteoarthritis and cartilage defect treatment | 华东师范大学 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021068943-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | 成都麻沸散医药科技有限公司 | 2021-04-15 | — | — | WO | disclosed |
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| CN-108929281-A | Triazole compound and synthesis method and application thereof | 华东师范大学 | 2018-12-04 | — | — | CN | disclosed |
| US-9884847-B2 | Indazole retinoic acid receptor-related orphan receptor modulators and uses thereof | INNOV17 LLC (US) | 2018-02-06 | — | — | US | disclosed |
| WO-2017184549-A1 | PYRROLOPYRIDINE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF | INNOV17 LLC (US) | 2017-10-26 | — | — | WO | disclosed |
| US-8481549-B2 | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents | THERAVANCE, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| WO-2011090929-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011090929-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| US-20110178101-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-07-21 | — | — | US | disclosed |
| US-20110178101-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-07-21 | — | — | US | disclosed |
| CN-1044235-C | Sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 1999-07-21 | — | — | CN | disclosed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| CN-1079468-A | Sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 1993-12-15 | — | — | CN | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |