SCHEMBL2945943

SCHEMBL2945943

CCOC(=O)C#CC(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
ALDH1A1 P00352 7/20 0.43
LMNA P02545 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ALOX15 P16050 1/20 0.40
SOAT1 P35610 1/20 0.40
TRPA1 O75762 1/20 0.37
TSHR P16473 1/20 0.35
EGLN1 Q9GZT9 1/20 0.34
KDM4E B2RXH2 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
MAPT P10636 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
PKM P14618 1/20 0.32
CYP2D6 P10635 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2939615 0.91 GAA (0.42) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL18446 0.89 ALDH1A1 (0.53) GAAMGAMSIMGAM2ALDH1A1
Ether SCHEMBL28615296 0.82 MGAM (0.36) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL16811766 0.82 ALDH1A1 (0.50) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL2945975 0.81 HCAR2 (0.38) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL25706 0.81 ALDH1A1 (0.44) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL6824967 0.80 ALDH1A1 (0.48) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL1857628 0.80 ALDH1A1 (0.43) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL2948744 0.79 ALDH1A1 (0.48) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL7736670 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4347346-A DIALKYLACETYLENEDICARBOXYITE TO PREVENT PREMATURE GELATION GENERAL ELECTRIC COMPANY (US) 1982-08-31 US claimed
US-11974991-B1 Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates King Faisal University (SA) 2024-05-07 US disclosed
US-11530217-B1 Antitubercular compounds King Faisal University (SA) 2022-12-20 US disclosed
WO-2017032780-A1 COMPOSITION FOR FORMING TRANSPARENT CONDUCTIVE LAYER AND METHOD FOR PREPARING THE SAME SOLVAY SA (BE) 2017-03-02 WO disclosed
EP-3135736-A1 COMPOSITION FOR FORMING TRANSPARENT CONDUCTIVE LAYER Solvay SA (BE) 2017-03-01 EP disclosed
CN-105793363-A Conductive compositions and layers made therefrom 索尔维公司 2016-07-20 CN disclosed
WO-2016097128-A1 PROCESS FOR PRODUCING POLYVINYLMETALLOCENE, AND POLYVINYLMETALLOCENE COMPOUND OBTAINED THEREFROM SOLVAY SA (BE) 2016-06-23 WO disclosed
WO-2016071484-A1 COMPOSITION FOR FORMING TRANSPARENT CONDUCTIVE LAYER AND METHOD FOR PREPARING THE SAME SOLVAY SA (BE) 2016-05-12 WO disclosed
WO-2015075181-A1 CONDUCTIVE COMPOSITION AND LAYER MA DE THEREFROM SOLVAY SA (BE) 2015-05-28 WO disclosed
EP-2876141-A1 Conductive polymer composition and layer made therefrom Solvay SA (BE) 2015-05-27 EP disclosed
US-20080038644-A1 Nonaques Electrolyte Solution And Lithium Secondary Battery Using Same UBE INDUSTRIES, LTD. (JP) 2008-02-14 US disclosed
WO-2007146603-A2 ADHESION PROMOTING ADDITIVE AVERY DENNISON CORPORATION (US) 2007-12-21 WO disclosed
CN-1961452-A Nonaqueous electrolyte solution and lithium secondary battery using same UBE INDUSTRIES (JP) 2007-05-09 CN disclosed
EP-1758198-A1 NONAQUEOUS ELECTROLYTE SOLUTION AND LITHIUM SECONDARY BATTERY USING SAME Ube Industries, Ltd. (JP) 2007-02-28 EP disclosed
EP-0391163-B1 Adherent silicone coating GEN ELECTRIC (US) 1995-03-08 EP disclosed
US-5082871-A Acetylenedicarboxylate gelation inhibitor GENERAL ELECTRIC COMPANY (US) 1992-01-21 US disclosed
EP-0391163-A2 Adherent silicone coating GENERAL ELECTRIC COMPANY (US) 1990-10-10 EP disclosed
US-4943601-A Coating with improved adhesion GENERAL ELECTRIC COMPANY (US) 1990-07-24 US disclosed
US-4347346-A DIALKYLACETYLENEDICARBOXYITE TO PREVENT PREMATURE GELATION GENERAL ELECTRIC COMPANY (US) 1982-08-31 US disclosed
US-4340710-A ETHYLENICALLY UNSATURATED ISOCYANURATE AND DIALKYL ACETYLENEDICARBOXYLATE STABILIZERS TO INHIBIT PREMATURE GELATION GENERAL ELECTRIC COMPANY (US) 1982-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11974991-B1 Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates ADORA2A, ADORA1, ADORA3 GAA 2856/4885MGAM 3821/4885SI 2645/4885
US-11530217-B1 Antitubercular compounds MT-CO3, NOS3, MT-ND3 GAA 4322/4885MGAM 3104/4885SI 4233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.