Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221088 | 0.81 | PGR (0.33) | PGR | |
| SCHEMBL13274575 | 0.81 | HDAC1 (0.33) | ADORA2APGR | |
| SCHEMBL2351533 | 0.80 | MET (0.39) | — | |
| SCHEMBL2268618 | 0.80 | ADORA2A (0.35) | ADORA2AADORA1NR1H2NR1H3 | |
| SCHEMBL13274793 | 0.79 | MET (0.43) | — | |
| SCHEMBL2223533 | 0.77 | MET (0.40) | CTSS | |
| SCHEMBL13274837 | 0.77 | MET (0.42) | ADORA2A | |
| SCHEMBL2220189 | 0.75 | MET (0.38) | — | |
| SCHEMBL12517966 | 0.73 | MET (0.55) | — | |
| SCHEMBL13274666 | 0.72 | LMNA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |