Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 7/20 | 0.71 |
| ▸ | GAA | P10253 | 5/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854377 | 0.89 | MAPT (0.65) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL9854205 | 0.85 | MAPT (0.58) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL2228950 | 0.85 | MAPT (0.60) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL12756285 | 0.85 | MAPT (0.81) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL13187322 | 0.83 | KMT2A (1.00) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL19644103 | 0.83 | GAA (0.58) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL29389131 | 0.83 | GAA (0.58) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL5468055 | 0.82 | KMT2A (0.66) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL643536 | 0.82 | POLB (0.75) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL5476546 | 0.82 | KMT2A (0.69) | KMT2AMAPTMEN1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684354-B1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2023-11-15 | — | — | EP | disclosed |
| US-20220089577-A1 | KU INHIBITORS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2022-03-24 | — | — | US | disclosed |
| EP-3463371-B1 | KU INHIBITORS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2022-02-23 | — | — | EP | disclosed |
| US-11207296-B2 | XPA inhibitor compounds and their use | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200308154-A1 | KU INHIBITORS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-10-01 | — | — | US | disclosed |
| EP-3684354-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | Indiana University Research and Technology Corporation (US) | 2020-07-29 | — | — | EP | disclosed |
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-07-16 | — | — | US | disclosed |
| EP-3463371-A1 | KU INHIBITORS AND THEIR USE | Indiana University Research & Technology Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2019060260-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-03-28 | — | — | WO | disclosed |
| WO-2017205503-A1 | KU INHIBITORS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2017-11-30 | — | — | WO | disclosed |
| US-7285663-B2 | β-Isoindigo coloring agent | CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) | 2007-10-23 | — | — | US | disclosed |
| EP-1223944-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1587877-B1 | BETA-ISOINDIGO COLORING AGENT | CLARIANT PRODUKTE DEUTSCHLAND (DE) | 2006-06-14 | — | — | EP | disclosed |
| US-20060041034-A1 | B-isoindigo coloring agent | CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) | 2006-02-23 | — | — | US | disclosed |
| EP-1587877-A1 | BETA-ISOINDIGO COLORING AGENT | Clariant GmbH (DE) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004065490-A1 | ss-ISOINDIGO COLORING AGENT | CLARIANT GMBH (DE) | 2004-08-05 | — | — | WO | disclosed |
| US-6552008-B1 | Administering effective amount of a selected azo-pyrazole derivative for therapy of thrombocytopenia | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | disclosed |
| EP-1223944-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1223944-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001021180-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089577-A1 | KU INHIBITORS AND THEIR USE | ZFR, XRCC6, ZFX | KMT2A 317/4885MAPT 3583/4885MEN1 2172/4885 |
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | XPOT, XPA, ERCC4 | KMT2A 1736/4885MAPT 3599/4885MEN1 884/4885 |
| US-11207296-B2 | XPA inhibitor compounds and their use | XPOT, XPA, ERCC4 | KMT2A 1736/4885MAPT 3599/4885MEN1 884/4885 |
| US-20200308154-A1 | KU INHIBITORS AND THEIR USE | ZFR, XRCC6, ZFX | KMT2A 317/4885MAPT 3583/4885MEN1 2172/4885 |
| US-20060041034-A1 | B-isoindigo coloring agent | IPO11, BBOX1, IPO4 | KMT2A 3242/4885MAPT 2428/4885MEN1 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.