SCHEMBL22213480

SCHEMBL22213480

CNC(C(=O)N1CC2(CCCN2C(=O)OCc2ccccc2)C1=O)C(C)O

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 1/20 0.38
GRIN2C Q14957 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7932040 0.91 CTSL (0.46)
SCHEMBL7933725 0.91 CTSL (0.46)
SCHEMBL12047518 0.90 CTSL (0.41)
SCHEMBL17070985 0.89 GRIN2B (0.40) GRIN2BGRIN2C
SCHEMBL16646195 0.87 GRIN2B (0.41) GRIN2BGRIN2C
SCHEMBL17030274 0.87 GRIN2B (0.41) GRIN2BGRIN2C
SCHEMBL12028815 0.85
SCHEMBL18538176 0.85 HTT (0.37) GRIN2BGRIN2C
SCHEMBL12028816 0.84 SLC15A1 (0.39)
SCHEMBL12028817 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3679931-A2 METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, AND OTHER DISORDERS Northwestern University (US) 2020-07-15 EP disclosed