Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 19/20 | 0.71 |
| ▸ | DRD3 | P35462 | 13/20 | 0.59 |
| ▸ | DRD2 | P14416 | 12/20 | 0.59 |
| ▸ | DRD4 | P21917 | 7/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | SCN1A | P35498 | 2/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492481 | 0.85 | OPRM1 (0.63) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL6842012 | 0.83 | OPRM1 (0.60) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL9790173 | 0.83 | OPRM1 (0.58) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL2571840 | 0.83 | OPRM1 (1.00) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL6836914 | 0.82 | OPRM1 (0.69) | OPRM1DRD3DRD2DRD4OPRD1 | |
| Bromide SCHEMBL8206195 | 0.82 | OPRM1 (0.58) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL6841059 | 0.81 | OPRM1 (0.57) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL6841483 | 0.79 | OPRM1 (0.55) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL9721660 | 0.79 | OPRM1 (0.52) | OPRM1DRD3DRD2DRD4OPRD1 | |
| SCHEMBL9721502 | 0.79 | OPRM1 (0.52) | OPRM1DRD3DRD2DRD4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521711-A1 | QUATERNARY AMMONIUM SALT PRODRUGS | Alkermes, Inc. (US) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011084846-A1 | QUATERNARY AMMONIUM SALT PRODRUGS | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |