Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.53 |
| ▸ | CBS | P35520 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21857630 | 0.72 | CDK5 (0.49) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| SCHEMBL32662696 | 0.70 | CBS (0.70) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| SCHEMBL219729 | 0.69 | BCL9 (0.49) | CDK5CDK5R1PTPN1CYP3A4HPGD | |
| Cupressuflavone SCHEMBL31670258 | 0.69 | CBS (1.00) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| Cupressuflavone SCHEMBL505213 | 0.69 | CBS (1.00) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| SCHEMBL24088771 | 0.68 | CBS (0.82) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| Cupressuflavone SCHEMBL4650575 | 0.68 | CBS (0.97) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| SCHEMBL30442786 | 0.68 | CBS (0.82) | CDK5CDK5R1CBSPTPN1CYP3A4 | |
| SCHEMBL16436195 | 0.68 | ESR1 (0.56) | CYP3A4HPGDKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12867826 | 0.67 | EGFR (0.62) | CYP3A4HPGDMAPTKDM4EAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2508182-B1 | Hydralazine for use in the treatment of age-related macular degeneration | TEXAS A & M UNIV SYS (US) | 2016-07-06 | — | — | EP | disclosed |
| EP-2508183-B1 | Interleukin-1 blocker for use in the treatment of age-related macular degeneration | TEXAS A & M UNIV SYS (US) | 2014-07-09 | — | — | EP | disclosed |
| US-20130059841-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2013-03-07 | — | — | US | disclosed |
| US-8318741-B2 | Therapeutic compositions and methods | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2012-11-27 | — | — | US | disclosed |
| EP-2508183-A1 | Interleukin-1 blocker for use in the treatment of age-related macular degeneration | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2012-10-10 | — | — | EP | disclosed |
| EP-2508182-A1 | Hydralazine for use in the treatment of age-related macular degeneration | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2012-10-10 | — | — | EP | disclosed |
| US-20120196868-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2012-08-02 | — | — | US | disclosed |
| US-20120115959-A1 | Therapeutic Compositions And Methods | THE TEXAS A&M UNIVERSITY SYSTEM | 2012-05-10 | — | — | US | disclosed |
| US-20120071485-A1 | Therapeutic Compositions And Methods | THE TEXAS A&M UNIVERSITY SYSTEM | 2012-03-22 | — | — | US | disclosed |
| US-8088773-B2 | Therapeutic compositions and methods | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2012-01-03 | — | — | US | disclosed |
| EP-1885371-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | The Texas A & M University System (US) | 2008-02-13 | — | — | EP | disclosed |
| US-20060276458-A1 | Therapeutic compositions and methods | THE TEXAS A & M UNIVERSITY SYSTEM | 2006-12-07 | — | — | US | disclosed |
| WO-2006124324-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276458-A1 | Therapeutic compositions and methods | PDE6H, PDE6C, PDE6D | CDK5 1561/4885CDK5R1 2236/4885CBS 2145/4885 |
| US-20120115959-A1 | Therapeutic Compositions And Methods | PDE6C, PDE6H, PDE6D | CDK5 1341/4885CDK5R1 1874/4885CBS 1721/4885 |
| US-20120071485-A1 | Therapeutic Compositions And Methods | PDE6H, PDE6C, PDE6D | CDK5 1561/4885CDK5R1 2236/4885CBS 2145/4885 |
| US-20120196868-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PDE6H, PDE6C, PDE6D | CDK5 1561/4885CDK5R1 2236/4885CBS 2145/4885 |
| US-20130059841-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PDE6H, PDE6C, PDE6D | CDK5 1561/4885CDK5R1 2236/4885CBS 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.