Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Cupressuflavone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 5/20 | 0.66 |
| ▸ | PARP2 known ✓ | Q9UGN5 | 4/20 | 0.66 |
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.60 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.60 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.60 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.60 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.60 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.60 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.60 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.60 |
| ▸ | SYK known ✓ | P43405 | 1/20 | 0.60 |
| ▸ | GSK3A known ✓ | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.60 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.60 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.60 |
| ▸ | CBS | P35520 | 2/20 | 0.97 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.97 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.97 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cupressuflavone SCHEMBL31670258 | 0.98 | CBS (1.00) | CBSPTPN1CDK5CDK5R1MAPT | |
| Cupressuflavone SCHEMBL505213 | 0.98 | CBS (1.00) | CBSPTPN1CDK5CDK5R1MAPT | |
| Agathisflavone SCHEMBL616142 | 0.88 | CBS (1.00) | CBSPTPN1CDK5CDK5R1MAPT | |
| Agathisflavone SCHEMBL30637380 | 0.88 | CBS (1.00) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL476215 | 0.86 | CBS (0.78) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL29435853 | 0.86 | CBS (0.78) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL28986431 | 0.86 | CBS (0.78) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL14066713 | 0.84 | CBS (0.74) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL15899618 | 0.83 | APP (0.77) | CBSPTPN1CDK5CDK5R1MAPT | |
| SCHEMBL29574181 | 0.83 | PTPN1 (1.00) | CBSPTPN1CDK5CDK5R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| EP-2730431-B1 | Rubber composition and tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2017-06-28 | — | — | EP | disclosed |
| US-20140135433-A1 | TIRE WITH RUBBER CONTAINING FLAVONE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2014-05-15 | — | — | US | disclosed |
| EP-2730431-A1 | Rubber composition and tire with rubber containing flavone | The Goodyear Tire & Rubber Company (US) | 2014-05-14 | — | — | EP | disclosed |
| EP-1391327-B1 | Tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2008-09-03 | — | — | EP | disclosed |
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1391327-A1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |