Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 5/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22223938 | 0.91 | RIPK1 (0.42) | RIPK1DYRK1AUSP30GSK3BGSK3A | |
| SCHEMBL22223939 | 0.83 | RIPK1 (0.38) | RIPK1DYRK1AUSP30GSK3BGSK3A | |
| SCHEMBL22208303 | 0.79 | RIPK1 (0.57) | RIPK1DYRK1AGSK3BHPGDSKCNH2 | |
| SCHEMBL22208366 | 0.73 | LMNA (0.41) | USP30GSK3BGSK3AMAPK1 | |
| SCHEMBL20288295 | 0.71 | KDM1A (0.48) | KDM1AMAOBMAPK1 | |
| SCHEMBL5197638 | 0.70 | CA1 (0.47) | USP30HPGDSKDM1A | |
| SCHEMBL22224035 | 0.69 | RIPK1 (0.59) | RIPK1DYRK1AUSP30GSK3BKCNH2 | |
| SCHEMBL20288336 | 0.69 | KDM1A (0.53) | KDM1A | |
| SCHEMBL20241180 | 0.69 | USP30 (0.45) | USP30GSK3BGSK3AIRAK4PDGFRB | |
| SCHEMBL28470232 | 0.68 | TSHR (0.41) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146858-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | ACCRO BIOSCIENCE INC. (KY) | 2020-07-16 | — | — | WO | disclosed |