Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485560 | 0.87 | HTR3E (0.50) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL2224449 | 0.82 | HTR3E (0.47) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL2223004 | 0.82 | KDM4E (0.50) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL2221291 | 0.81 | KDM4E (0.52) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL2224333 | 0.80 | MAPT (0.61) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL14485519 | 0.78 | HSD11B1 (0.58) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL14485700 | 0.76 | HTR3E (0.45) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL2224288 | 0.76 | HTR3E (0.50) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| SCHEMBL2225563 | 0.74 | KDM4E (0.38) | ALDH1A1HTR3EHTR3BHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL2223708 | 0.73 | BCL2L1 (0.44) | ALDH1A1HTR3EHTR3BHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |