Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228025 | 0.79 | MAPT (0.56) | KDM4EMEN1KMT2AALDH1A1PPARG | |
| SCHEMBL27897390 | 0.79 | EPHX2 (0.41) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL2222751 | 0.74 | ALDH1A1 (0.46) | KDM4EMEN1KMT2AALDH1A1HTR3E | |
| SCHEMBL14485560 | 0.73 | HTR3E (0.50) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL19107154 | 0.72 | HRH4 (0.50) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| SCHEMBL26790144 | 0.71 | CYP1A2 (0.45) | KDM4EMEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL10094245 | 0.71 | CYP1A2 (0.49) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL14485700 | 0.70 | HTR3E (0.45) | KDM4EMEN1KMT2AALDH1A1HTR3E | |
| SCHEMBL2224288 | 0.70 | HTR3E (0.50) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL10094264 | 0.70 | CYP1A2 (0.52) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |