Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227674 | 0.88 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL28480626 | 0.83 | ROCK2 (0.63) | ROCK2 | |
| SCHEMBL17913013 | 0.82 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL22227628 | 0.81 | ROCK2 (0.54) | ROCK2 | |
| SCHEMBL28902528 | 0.79 | ROCK2 (0.64) | ROCK2 | |
| SCHEMBL22227672 | 0.78 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL22227679 | 0.78 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL28489999 | 0.76 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL19759680 | 0.76 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL22227671 | 0.74 | ROCK2 (0.59) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406426-B | Cyclic ureas as ROCK inhibitors | 百时美施贵宝公司 | 2020-11-20 | — | — | CN | claimed |
| EP-3242873-B1 | CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-07-22 | — | — | EP | disclosed |