Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227637 | 0.89 | ENPP2 (0.65) | ROCK2ENPP2TAS2R8 | |
| SCHEMBL28477382 | 0.83 | ROCK2 (0.62) | ROCK2 | |
| SCHEMBL22227686 | 0.81 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL17913013 | 0.81 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL22227644 | 0.79 | ROCK2 (0.60) | ROCK2ENPP2TAS2R8 | |
| SCHEMBL22227669 | 0.78 | ROCK2 (0.58) | ROCK2ENPP2TAS2R8 | |
| SCHEMBL22227645 | 0.78 | ROCK2 (0.59) | ROCK2ENPP2TAS2R8 | |
| SCHEMBL17912897 | 0.77 | ROCK2 (0.63) | ROCK2TAS2R8 | |
| SCHEMBL19759680 | 0.75 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL2387216 | 0.74 | TAS2R8 (0.55) | TAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406426-B | Cyclic ureas as ROCK inhibitors | 百时美施贵宝公司 | 2020-11-20 | — | — | CN | claimed |
| EP-3242873-B1 | CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-07-22 | — | — | EP | disclosed |