⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528666 | 0.84 | — | — | |
| SCHEMBL1313598 | 0.82 | ALDH1A1 (0.46) | — | |
| SCHEMBL6984030 | 0.80 | ALDH1A1 (0.50) | — | |
| SCHEMBL6984192 | 0.80 | ALDH1A1 (0.50) | — | |
| SCHEMBL7220771 | 0.77 | — | — | |
| SCHEMBL1264226 | 0.76 | — | — | |
| SCHEMBL15484812 | 0.74 | — | — | |
| SCHEMBL1266458 | 0.74 | SIGMAR1 (0.35) | — | |
| SCHEMBL9726702 | 0.74 | CA12 (0.31) | — | |
| SCHEMBL9547183 | 0.74 | MAPT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 957 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778576-B1 | 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | HANLIM PHARMACEUTICAL CO LTD (KR) | 2024-04-17 | — | — | EP | claimed |
| US-20210047301-A1 | 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | HANLIM PHARMACEUTICAL CO., LTD. (KR) | 2021-02-18 | — | — | US | claimed |
| EP-3778576-A1 | 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Hanlim Pharmaceutical Co., Ltd. (KR) | 2021-02-17 | — | — | EP | claimed |
| US-10584128-B2 | Bicyclic dihydropyrimidine-carboxamide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-10 | — | — | US | claimed |
| CN-106674176-B | 7-substituted-4-aryl coumarin compound and preparation method and application thereof | 西安交通大学 | 2019-12-24 | — | — | CN | claimed |
| EP-3558999-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2019-10-30 | — | — | EP | claimed |
| WO-2019190117-A1 | 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | 한림제약(주) | 2019-10-03 | — | — | WO | claimed |
| CN-110062758-A | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | 奇斯药制品公司 | 2019-07-26 | — | — | CN | claimed |
| WO-2018115383-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-06-28 | — | — | WO | claimed |
| US-20180170939-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTISI S.p.A. (IT) | 2018-06-21 | — | — | US | claimed |
| EP-0165897-A2 | Resorcin ethers | CIBA-GEIGY AG (CH) | 1985-12-27 | — | — | EP | claimed |
| EP-0055099-B1 | PENICILLIN DERIVATIVES | ICI PHARMA (FR) | 1984-10-24 | — | — | EP | claimed |
| EP-0075434-A2 | Cephalosporins, their preparation and their pharmaceutical compositions | ICI PHARMA (FR) | 1983-03-30 | — | — | EP | claimed |
| EP-0072608-A2 | Process for the preparation of cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-02-23 | — | — | EP | claimed |
| EP-0071370-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | ICI PHARMA (FR) | 1983-02-09 | — | — | EP | claimed |
| EP-0055562-A2 | Cephalosporin derivatives | ICI PHARMA (FR) | 1982-07-07 | — | — | EP | claimed |
| EP-0055099-A1 | Penicillin derivatives | ICI PHARMA (FR) | 1982-06-30 | — | — | EP | claimed |
| US-4128564-A | 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins | MERCK & CO., INC. (US) | 1978-12-05 | — | — | US | claimed |
| US-4059587-A | 8-AZA-9-OXO-11-THIA-PROSTANOIC ACID DERIVATIVES; VASODILATORS, ANTICLOTTING, REGULATORS OF IMMUNE RESPONSE | MERCK & CO., INC. (US) | 1977-11-22 | — | — | US | claimed |
| US-4022794-A | VASODILATION | MERCK & CO., INC. (US) | 1977-05-10 | — | — | US | claimed |