SCHEMBL22231963

SCHEMBL22231963

CCN(C)/C=N/c1cc(F)cc(NCc2cnc(C)cn2)c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 16/20 0.37
CLK4 Q9HAZ1 12/20 0.37
CYP3A4 P08684 12/20 0.37
ALDH1A1 P00352 11/20 0.37
HSD17B10 Q99714 9/20 0.37
TP53 P04637 1/20 0.37
CYP2C19 P33261 6/20 0.35
TSHR P16473 5/20 0.35
CYP2C9 P11712 1/20 0.35
TMEM97 Q5BJF2 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
CYP2D6 P10635 6/20 0.35
ALOX15 P16050 6/20 0.34
IGF1R P08069 1/20 0.33
FGFR1 P11362 1/20 0.33
KDR P35968 1/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
USP2 O75604 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22231965 1.00 CYP1A2 (0.37) CYP1A2CLK4CYP3A4ALDH1A1HSD17B10
SCHEMBL22231926 0.80 CYP1A2 (0.38) CYP1A2CLK4CYP3A4ALDH1A1HSD17B10
SCHEMBL22231923 0.80 CYP1A2 (0.38) CYP1A2CLK4CYP3A4ALDH1A1HSD17B10
SCHEMBL22232432 0.75 MMP13 (0.32) MEN1KMT2AMAPTTDP1
SCHEMBL22232429 0.75 MMP13 (0.32) MEN1KMT2AMAPTTDP1
SCHEMBL22232036 0.74
SCHEMBL22232033 0.74
SCHEMBL22232433 0.73 RAPGEF4 (0.33)
SCHEMBL22232436 0.73 RAPGEF4 (0.33)
SCHEMBL22232194 0.73 CYP1A2 (0.40) CYP1A2CLK4CYP3A4ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US claimed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US claimed
EP-3911629-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2021-11-24 EP claimed
WO-2020148617-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-07-23 WO claimed
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed
EP-3911629-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2021-11-24 EP disclosed
WO-2020148617-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS CYP1A2 144/4885CLK4 3934/4885CYP3A4 412/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS CYP1A2 365/4885CLK4 2105/4885CYP3A4 264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.