SCHEMBL22232124

SCHEMBL22232124

Cc1cc(N)c(Cl)c(Cc2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.44
GRIN2B Q13224 1/20 0.39
MAOB P27338 3/20 0.38
TAAR1 Q96RJ0 1/20 0.38
LTA4H P09960 1/20 0.37
IDO1 P14902 2/20 0.37
MBOAT4 Q96T53 2/20 0.36
HSP90AA1 P07900 1/20 0.36
LDHA P00338 1/20 0.36
LDHB P07195 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
CHRM4 P08173 1/20 0.35
SLC5A2 P31639 2/20 0.35
CRHR1 P34998 1/20 0.34
SRD5A2 P31213 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22231828 0.85 HTR2A (0.46) MAOBTAAR1LTA4HIDO1MRGPRX4
SCHEMBL22232238 0.84 CYP3A4 (0.38) TAAR1LTA4HIDO1SLC5A2
SCHEMBL22232016 0.83 ADCY10 (0.41) TAAR1HSP90AA1
SCHEMBL22231708 0.82 SLC6A4 (0.46) GRIN2BMBOAT4SLC5A2
SCHEMBL28642114 0.81 SLC6A4 (0.39) IDO1
SCHEMBL22231931 0.80 MAPT (0.36) MAOBTAAR1
SCHEMBL29454241 0.80 CYP3A4 (0.41) IDH1
SCHEMBL22232349 0.80 CYP3A4 (0.41) IDH1
SCHEMBL22232561 0.78 NPSR1 (0.46) IDH1TAAR1LTA4HIDO1
SCHEMBL22232495 0.78 IDH1 (0.45) IDH1MAOBSLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US claimed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP claimed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US claimed
EP-3911629-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2021-11-24 EP claimed
WO-2020148617-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-07-23 WO claimed
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed
EP-3911629-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2021-11-24 EP disclosed
WO-2020148617-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS IDH1 592/4885GRIN2B 766/4885MAOB 74/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS IDH1 626/4885GRIN2B 3336/4885MAOB 1930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.