Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17656783 | 0.76 | CHRM1 (0.48) | P2RX7CHRM1 | |
| SCHEMBL2223239 | 0.72 | P2RX7 (0.33) | ADORA2AP2RX7CHRM1 | |
| SCHEMBL12803022 | 0.72 | CHRM1 (0.55) | CHRM1 | |
| SCHEMBL12802494 | 0.72 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2224850 | 0.67 | GRM2 (0.46) | ADORA2A | |
| SCHEMBL6890674 | 0.66 | CHRM1 (0.49) | CHRM1 | |
| SCHEMBL17585463 | 0.66 | CHRM1 (0.48) | CHRM1 | |
| SCHEMBL6892942 | 0.65 | CHRM1 (0.49) | CHRM1 | |
| SCHEMBL12803346 | 0.65 | CHRM1 (0.54) | CHRM1 | |
| SCHEMBL17296540 | 0.64 | CHRM1 (0.56) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |