SCHEMBL22232452

SCHEMBL22232452

Cc1cc(N)c(C)c(Cc2ccc(F)cc2)c1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.40
RET P07949 1/20 0.40
KDR P35968 1/20 0.40
MPO P05164 1/20 0.40
CNR2 P34972 2/20 0.40
GPR55 Q9Y2T6 2/20 0.40
ADCY10 Q96PN6 1/20 0.38
CNR1 P21554 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.38
SLC6A2 P23975 3/20 0.37
SLC6A4 P31645 3/20 0.37
SLC6A3 Q01959 3/20 0.37
ACHE P22303 1/20 0.37
TAAR1 Q96RJ0 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29454289 1.00 MAPT (0.40) MAPTRETKDRMPOCNR2
SCHEMBL22232129 0.87 MPO (0.41) MAPTRETKDRMPOCNR2
SCHEMBL22232155 0.87 TDP1 (0.41) CNR2ACHETAAR1
SCHEMBL28965174 0.85 MAPT (0.42) MAPTRETKDRMPOCNR2
SCHEMBL22232016 0.85 ADCY10 (0.41) MAPTRETKDRMPOCNR2
SCHEMBL22231733 0.83 ADCY10 (0.42) MAPTRETKDRMPOCNR2
SCHEMBL22232549 0.82 KMT2A (0.42) MAPTMPOCNR2ADCY10SLC6A2
SCHEMBL22232363 0.82 RET (0.40) MAPTRETKDRCNR2SLC6A2
SCHEMBL22232243 0.82 MAPT (0.38) MAPTTAAR1
SCHEMBL22897871 0.82 SLC6A2 (0.48) MAPTRETKDRMPOCNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US claimed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP claimed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US claimed
CN-113454063-A 3-substituted phenylamidine compounds, preparation method and application thereof PI工业有限公司 2021-09-28 CN claimed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP disclosed
EP-3911629-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2021-11-24 EP disclosed
CN-113454063-A 3-substituted phenylamidine compounds, preparation method and application thereof PI工业有限公司 2021-09-28 CN disclosed
WO-2020148617-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS MAPT 3811/4885RET 1326/4885KDR 3667/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS MAPT 4483/4885RET 3173/4885KDR 3931/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.