Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222330 | 0.84 | HDAC1 (0.46) | HDAC1HDAC8HDAC6S1PR1S1PR3 | |
| SCHEMBL2223392 | 0.77 | HDAC1 (0.41) | HDAC1HDAC8HDAC6S1PR1S1PR3 | |
| SCHEMBL5540418 | 0.71 | PDE4B (0.50) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL2222160 | 0.71 | HDAC1 (0.41) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL14294336 | 0.70 | LMNA (0.52) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL2224672 | 0.68 | MAOA (0.38) | HDAC1HDAC8HDAC6S1PR1S1PR3 | |
| SCHEMBL14672201 | 0.68 | LMNA (0.39) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL5540408 | 0.68 | HDAC1 (0.50) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL2224843 | 0.67 | LMNA (0.59) | HDAC1HDAC8HDAC6LMNAPDE4B | |
| SCHEMBL1543126 | 0.67 | LMNA (0.52) | HDAC1HDAC8HDAC6LMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |