Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235343 | 1.00 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29728904 | 1.00 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL22235514 | 1.00 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL22235426 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1HPGDDHODHMAPT | |
| SCHEMBL29728931 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1HPGDDHODHMAPT | |
| SCHEMBL22235748 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1HPGDDHODHMAPT | |
| SCHEMBL22235429 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1HPGDDHODHMAPT | |
| SCHEMBL22236137 | 0.81 | GABRG2 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL22235484 | 0.80 | ALDH1A1 (0.34) | KDM4EALDH1A1HPGDALOX15NPC1 | |
| SCHEMBL22235323 | 0.80 | ALDH1A1 (0.34) | KDM4EALDH1A1HPGDALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113825756-A | Substituted polycyclic carboxylic acids, analogs thereof, and methods of use thereof | 爱彼特生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| EP-3911653-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020150366-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-07-23 | — | — | WO | disclosed |