Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.55 |
| ▸ | CLK2 | P49760 | 6/20 | 0.55 |
| ▸ | CLK3 | P49761 | 5/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236034 | 0.85 | DYRK1A (0.54) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236128 | 0.84 | DYRK1A (0.54) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236007 | 0.84 | DYRK1A (0.76) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236026 | 0.83 | DYRK1A (0.75) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235823 | 0.82 | DYRK1A (0.76) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236190 | 0.81 | DYRK1A (0.52) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235620 | 0.81 | DYRK1A (0.75) | DYRK1ACLK2CLK3GSK3BPDE4A | |
| SCHEMBL22235679 | 0.80 | LMNA (0.68) | DYRK1ACLK2CLK3ALDH1A1LMNA | |
| SCHEMBL22236176 | 0.78 | DYRK1A (0.47) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235785 | 0.78 | DYRK1A (0.47) | DYRK1ACLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |