Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22258491 | 0.87 | RAB9A (0.37) | NPC1RAB9AMAPTRECQLVNN1 | |
| SCHEMBL22258246 | 0.86 | NOS1 (0.40) | NPC1RAB9AMAPTRECQLALDH1A1 | |
| SCHEMBL22258247 | 0.81 | CDK5 (0.49) | — | |
| SCHEMBL22258549 | 0.81 | LTA4H (0.47) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL3823084 | 0.77 | AURKA (0.57) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL22258553 | 0.76 | HSD17B10 (0.40) | HPGDSMN1; SMN2 | |
| SCHEMBL22258481 | 0.75 | EGFR (0.55) | NPC1RAB9AMAPTKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL2267257 | 0.74 | AURKA (0.52) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL22258552 | 0.74 | LTA4H (0.48) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22236222 | 0.74 | RXFP1 (0.49) | NPC1RAB9AMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |