Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.57 |
| ▸ | CLK2 | P49760 | 5/20 | 0.57 |
| ▸ | CLK3 | P49761 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP36 | Q9P275 | 4/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236002 | 0.90 | CLK2 (0.45) | DYRK1ACLK2CLK3TDO2USP36 | |
| SCHEMBL22236189 | 0.90 | DYRK1A (0.59) | DYRK1ACLK2CLK3GSK3BMAPK7 | |
| SCHEMBL22235838 | 0.89 | DYRK1A (0.59) | DYRK1ACLK2CLK3GSK3BMAPK7 | |
| SCHEMBL22236116 | 0.88 | DYRK1A (0.64) | DYRK1ACLK2CLK3GSK3BMAPK7 | |
| SCHEMBL22236229 | 0.86 | DYRK1A (0.76) | DYRK1ACLK2CLK3GSK3BMAPK7 | |
| SCHEMBL22235745 | 0.84 | SMN1; SMN2 (0.62) | DYRK1ACLK2CLK3GSK3BSMN1; SMN2 | |
| SCHEMBL22236050 | 0.82 | CLK2 (0.57) | DYRK1ACLK2CLK3USP36WNT1 | |
| SCHEMBL22236223 | 0.81 | USP36 (0.50) | DYRK1ACLK2USP36WNT1 | |
| SCHEMBL22258271 | 0.80 | USP36 (0.53) | DYRK1ACLK2CLK3SMN1; SMN2USP36 | |
| SCHEMBL22235785 | 0.80 | DYRK1A (0.47) | DYRK1ACLK2CLK3GSK3BMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |