Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 14/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222078 | 0.93 | ELOVL1 (0.38) | ELOVL1TP53 | |
| SCHEMBL2223717 | 0.91 | KMT2A (0.33) | TP53THRB | |
| SCHEMBL2222006 | 0.88 | GRM2 (0.40) | TP53GRM2 | |
| SCHEMBL2221099 | 0.87 | TP53 (0.38) | TP53GRM2 | |
| SCHEMBL2223741 | 0.86 | PDE10A (0.34) | TP53THRB | |
| SCHEMBL2221341 | 0.85 | PDE10A (0.33) | TP53 | |
| SCHEMBL2220259 | 0.83 | TP53 (0.36) | TP53 | |
| SCHEMBL2221804 | 0.83 | ENPP2 (0.35) | TP53GRM2 | |
| SCHEMBL2219994 | 0.83 | MEN1 (0.37) | — | |
| SCHEMBL13275659 | 0.81 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |