Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.48 |
| ▸ | VEGFA | P15692 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 3/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.48 |
| ▸ | TET3 | O43151 | 1/20 | 0.48 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.48 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.48 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.48 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.48 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.48 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15153839 | 0.85 | ALOX5 (0.51) | ALOX5EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL14122956 | 0.84 | ALOX15 (0.45) | ALOX15MAP4K4ADORA2AADORA1ADORA2B | |
| SCHEMBL30957058 | 0.84 | ALOX15 (0.45) | ALOX15MAP4K4ADORA2AADORA1ADORA2B | |
| SCHEMBL24011999 | 0.82 | PIK3CD (0.59) | FYNALOX15MAP4K4ADORA2AADORA1 | |
| SCHEMBL22239389 | 0.82 | ESR2 (0.47) | ESR2ALOX15MAP4K4ADORA2AADORA1 | |
| SCHEMBL23501739 | 0.79 | ALOX5 (0.59) | ALOX5EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL22326630 | 0.78 | KDM4E (0.41) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL20248019 | 0.78 | ALOX15 (0.43) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL31104706 | 0.78 | FYN (0.52) | EGLN1VEGFAFLT1EGLN3FYN | |
| SCHEMBL14122536 | 0.78 | FYN (0.52) | EGLN1VEGFAFLT1EGLN3FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683209-A1 | PROCESS FOR PREPARING [(5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL)-AMINO]ACETIC ACID FROM 5-((3-CHLOROPHENYL)-3-CHLORO-PYRIDIN-2-YL)-NITRILE, AND PROCESS FOR PREPARING 5-((HALOPHENYL)-3-HALO-PYRIDIN-2-YL)-NITRILE DERIVATIVES | Akebia Therapeutics Inc. (US) | 2020-07-22 | — | — | EP | disclosed |