Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19935819 | 0.84 | MAP4K4 (0.44) | SMN1; SMN2RAB9ANPC1LMNAMAP4K4 | |
| SCHEMBL14122956 | 0.84 | ALOX15 (0.45) | ALOX15SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL30957058 | 0.84 | ALOX15 (0.45) | ALOX15SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL24011999 | 0.82 | PIK3CD (0.59) | ALOX15MAP4K4ADORA1ADORA2AADORA2B | |
| SCHEMBL22239386 | 0.82 | ALOX5 (0.51) | ESR2ALOX15SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31104706 | 0.81 | FYN (0.52) | ALOX15SMN1; SMN2NPC1MAPTLMNA | |
| SCHEMBL20248019 | 0.81 | ALOX15 (0.43) | ALOX15SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL14122536 | 0.81 | FYN (0.52) | ALOX15SMN1; SMN2NPC1MAPTLMNA | |
| SCHEMBL19393642 | 0.79 | KDM4E (0.47) | ALOX15SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL23319645 | 0.79 | ESR2 (0.54) | ESR2SMN1; SMN2RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683209-A1 | PROCESS FOR PREPARING [(5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL)-AMINO]ACETIC ACID FROM 5-((3-CHLOROPHENYL)-3-CHLORO-PYRIDIN-2-YL)-NITRILE, AND PROCESS FOR PREPARING 5-((HALOPHENYL)-3-HALO-PYRIDIN-2-YL)-NITRILE DERIVATIVES | Akebia Therapeutics Inc. (US) | 2020-07-22 | — | — | EP | disclosed |