Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239727 | 0.90 | HCRTR2 (0.43) | KMT2ARAB9AHCRTR1HCRTR2MAPK1 | |
| SCHEMBL17776972 | 0.87 | RAB9A (0.39) | KMT2AFGFR4RAB9AMAPTHCRTR1 | |
| SCHEMBL19714129 | 0.87 | RAB9A (0.39) | KMT2AFGFR4RAB9AMAPTHCRTR1 | |
| SCHEMBL19699129 | 0.86 | WNT3A (0.41) | KMT2AFGFR4HCRTR1 | |
| SCHEMBL17777112 | 0.85 | CNR1 (0.41) | KMT2AFGFR4RAB9AMAPTHCRTR1 | |
| SCHEMBL17769922 | 0.82 | KMT2A (0.37) | KMT2AFGFR4RAB9AMAPTHCRTR1 | |
| SCHEMBL17769927 | 0.82 | KMT2A (0.37) | KMT2AFGFR4RAB9AMAPTHCRTR1 | |
| SCHEMBL22239639 | 0.81 | MALT1 (0.35) | MAPTKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL17618519 | 0.80 | SCD (0.43) | — | |
| SCHEMBL16776518 | 0.80 | MAP4K4 (0.41) | KMT2AFGFR4HCRTR1HCRTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |