Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714129 | 1.00 | RAB9A (0.39) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL19714072 | 0.89 | NPC1 (0.39) | RAB9ANPC1SMN1; SMN2FGFR4CNR1 | |
| SCHEMBL17770026 | 0.89 | DEGS1 (0.37) | CRHR1PAK1ACKR3PDE4B | |
| SCHEMBL17777112 | 0.87 | CNR1 (0.41) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL22239718 | 0.87 | KMT2A (0.42) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL19713766 | 0.87 | RPS6KA3 (0.39) | RAB9ANPC1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL22239709 | 0.85 | DRD2 (0.39) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL16754448 | 0.85 | DRD2 (0.39) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL19714141 | 0.85 | PARP1 (0.40) | HCRTR1HSD11B1CXCR3 | |
| SCHEMBL17769922 | 0.85 | KMT2A (0.37) | RAB9ANPC1MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |