SCHEMBL2224170

SCHEMBL2224170

Cc1cc(-c2nc3cnc(Oc4cccc(Cl)c4)nc3o2)cc(C)c1OCC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 1.00
CETP P11597 2/20 0.42
CYP1A2 P05177 14/20 0.42
ALDH1A1 P00352 11/20 0.42
TSHR P16473 10/20 0.42
CYP2C19 P33261 10/20 0.42
PPARD Q03181 2/20 0.41
PPARG P37231 1/20 0.41
CYP3A4 P08684 11/20 0.41
CYP2C9 P11712 11/20 0.41
USP2 O75604 8/20 0.41
HSD17B10 Q99714 3/20 0.41
GLA P06280 2/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
CASP1 P29466 1/20 0.41
HIF1A Q16665 3/20 0.40
CYP2D6 P10635 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31615140 1.00 S1PR1 (1.00) S1PR1CETPCYP1A2ALDH1A1TSHR
SCHEMBL2221025 0.91 S1PR1 (0.83) S1PR1CETPALDH1A1TSHRPPARG
SCHEMBL2223368 0.91 S1PR1 (0.83) S1PR1CETPCYP1A2ALDH1A1TSHR
SCHEMBL14797011 0.90 S1PR1 (0.82) S1PR1CETPCYP1A2ALDH1A1TSHR
SCHEMBL2222062 0.90 S1PR1 (0.82) S1PR1CETPCYP1A2ALDH1A1PPARD
SCHEMBL2222592 0.89 S1PR1 (0.81) S1PR1CETPPPARDPPARGFFAR1
SCHEMBL14797179 0.88 S1PR1 (0.79) S1PR1CETPCYP1A2PPARDPPARG
SCHEMBL14797191 0.88 S1PR1 (0.79) S1PR1CETPPPARDPPARGLMNA
SCHEMBL14797114 0.88 S1PR1 (0.78) S1PR1CETPPPARDPPARGFFAR1
SCHEMBL14797145 0.87 S1PR1 (0.77) S1PR1ALDH1A1PPARDPPARGMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118697873-B Use of S1PR 1-biased agonists in the treatment of inflammatory bowel disease 四川大学华西医院 2026-05-12 CN claimed
CN-118697873-A Use of S1PR 1-biased agonists in the treatment of inflammatory bowel disease 四川大学华西医院 2024-09-27 CN claimed
EP-3057591-B1 4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY SANOFI SA (FR) 2021-09-08 EP claimed
US-9782411-B2 {4-[5-(3-chloro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid for use in the prevention or treatment of acute kidney injury SANOFI (FR) 2017-10-10 US claimed
EP-3057591-A1 4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY SANOFI (FR) 2016-08-24 EP claimed
US-20160235756-A1 4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY SANOFI (FR) 2016-08-18 US claimed
WO-2015055694-A1 4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY SANOFI (FR) 2015-04-23 WO claimed
EP-2862574-A1 {4-[5-(3-chloro-phenoxy)-oxazolo[5,4 d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid for use in the prevention or treatment of acute kidney injury SANOFI (FR) 2015-04-22 EP claimed
US-8846692-B2 Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring SANOFI (FR) 2014-09-30 US claimed
EP-2523962-B1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI SA (FR) 2013-11-27 EP claimed
US-20130079358-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-03-28 US claimed
CN-122097375-A Application of S1PR1 selective agonist SAR247799 in preparation of medicine for treating neuromyelitis Optica (OPYNAMIC) spectrum diseases 2026-05-29 CN disclosed
CN-122097375-A Application of S1PR1 selective agonist SAR247799 in preparation of medicine for treating neuromyelitis Optica (OPYNAMIC) spectrum diseases 2026-05-29 CN disclosed
CN-118697873-B Use of S1PR 1-biased agonists in the treatment of inflammatory bowel disease 四川大学华西医院 2026-05-12 CN disclosed
CN-118697873-B Use of S1PR 1-biased agonists in the treatment of inflammatory bowel disease 四川大学华西医院 2026-05-12 CN disclosed
US-8846692-B2 Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring SANOFI (FR) 2014-09-30 US disclosed
EP-2523962-B1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI SA (FR) 2013-11-27 EP disclosed
US-20130079358-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-03-28 US disclosed
EP-2523962-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2012-11-21 EP disclosed
WO-2011086079-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI-AVENTIS (FR) 2011-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079358-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING OXGR1, EDNRA, EDF1 S1PR1 129/4885CETP 3150/4885CYP1A2 790/4885
US-20160235756-A1 4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY REN, ATP6V1B1, AK2 S1PR1 1817/4885CETP 4400/4885CYP1A2 1765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.