Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222401 | 0.90 | S1PR1 (0.49) | S1PR1CYP3A4CYP1A2CYP2C9APP | |
| SCHEMBL2224638 | 0.89 | S1PR1 (0.48) | S1PR1ALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL2224156 | 0.87 | S1PR1 (0.47) | S1PR1CYP3A4CYP1A2CYP2C9APP | |
| SCHEMBL2225550 | 0.87 | S1PR1 (0.56) | S1PR1CYP3A4CYP1A2CYP2C9USP2 | |
| SCHEMBL2224142 | 0.87 | S1PR1 (0.51) | S1PR1CYP3A4CYP1A2CYP2C9APP | |
| SCHEMBL2228933 | 0.86 | S1PR1 (0.58) | S1PR1CYP3A4CYP1A2CYP2C9SLC6A3 | |
| SCHEMBL2222499 | 0.85 | S1PR1 (0.54) | S1PR1CYP3A4CYP1A2CYP2C9APP | |
| SCHEMBL14796972 | 0.85 | S1PR1 (0.68) | S1PR1CYP3A4CYP1A2CYP2C9SLC6A3 | |
| SCHEMBL2225909 | 0.83 | S1PR1 (0.54) | S1PR1CYP3A4CYP1A2CYP2C9APP | |
| SCHEMBL2223341 | 0.83 | S1PR1 (0.54) | S1PR1CYP3A4CYP1A2CYP2C9APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |