Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 7/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | CCNK | O75909 | 4/20 | 0.46 |
| ▸ | CCND3 | P30281 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22246276 | 0.94 | EGFR (0.49) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL30503703 | 0.92 | MAPK9 (0.55) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL30503705 | 0.92 | MAPK9 (0.53) | MAPK9MAPK10EGFRCCNA2CDK2 | |
| SCHEMBL22246278 | 0.90 | ALK (0.45) | MAPK9MAPK10EGFRALKMAPK8 | |
| SCHEMBL22246265 | 0.89 | EGFR (0.53) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL22246172 | 0.89 | MAPK9 (0.54) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL30503727 | 0.88 | MAPK9 (0.57) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL30948591 | 0.88 | MAPK9 (0.44) | MAPK9MAPK10EGFRALKMAPK8 | |
| SCHEMBL30503717 | 0.88 | MAPK9 (0.51) | MAPK9MAPK10EGFRALKCCNA2 | |
| SCHEMBL30503700 | 0.87 | EGFR (0.48) | MAPK9MAPK10EGFRALKCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113302196-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2020147702-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-07-23 | — | — | WO | disclosed |