Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22246276 | 0.92 | EGFR (0.49) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503703 | 0.91 | MAPK9 (0.55) | EGFRMAPK9MAPK10BRD4ALK | |
| SCHEMBL22246232 | 0.89 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| Trifluoroacetic Acid SCHEMBL29065781 | 0.89 | MAPK9 (0.55) | EGFRMAPK9MAPK10BRD4ALK | |
| SCHEMBL22246105 | 0.87 | EGFR (0.71) | EGFRALK | |
| Hydrochloric Acid SCHEMBL29400610 | 0.86 | EGFR (0.70) | EGFRALK | |
| SCHEMBL30948591 | 0.85 | MAPK9 (0.44) | EGFRMAPK9MAPK10BRD4ALK | |
| SCHEMBL30503700 | 0.84 | EGFR (0.48) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246247 | 0.84 | EGFR (0.52) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30948623 | 0.83 | EGFR (0.50) | EGFRMAPK9MAPK10ALKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020147702-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-07-23 | — | — | WO | disclosed |