Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNK | O75909 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22246232 | 0.94 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503703 | 0.94 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503700 | 0.93 | EGFR (0.48) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246265 | 0.92 | EGFR (0.53) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246247 | 0.90 | EGFR (0.52) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30948591 | 0.90 | MAPK9 (0.44) | EGFRMAPK9MAPK10ALKMAPK8 | |
| Trifluoroacetic Acid SCHEMBL29065781 | 0.89 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246255 | 0.88 | EGFR (0.48) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503699 | 0.88 | EGFR (0.49) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246290 | 0.87 | EGFR (0.46) | EGFRMAPK9MAPK10ALKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113302196-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2020147702-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-07-23 | — | — | WO | disclosed |