Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNK | O75909 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396776 | 0.87 | EGFR (0.62) | EGFRALK | |
| SCHEMBL22246231 | 0.87 | EGFR (0.62) | EGFRALK | |
| SCHEMBL22246276 | 0.87 | EGFR (0.49) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246255 | 0.87 | EGFR (0.48) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246247 | 0.86 | EGFR (0.52) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503703 | 0.82 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246232 | 0.82 | MAPK9 (0.55) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30948623 | 0.80 | EGFR (0.50) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL30503700 | 0.80 | EGFR (0.48) | EGFRMAPK9MAPK10ALKMAPK8 | |
| SCHEMBL22246225 | 0.80 | MAPK9 (0.52) | EGFRMAPK9MAPK10ALKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020147702-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-07-23 | — | — | WO | disclosed |