Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223548 | 0.83 | S1PR1 (0.42) | S1PR1ALDH1A1KDM4ESMN1; SMN2APP | |
| SCHEMBL2224907 | 0.82 | S1PR1 (0.42) | S1PR1ALDH1A1KDM4ESMN1; SMN2APP | |
| SCHEMBL14486171 | 0.80 | APP (0.44) | S1PR1ALDH1A1KDM4ESMN1; SMN2APP | |
| SCHEMBL14486843 | 0.78 | SMN1; SMN2 (0.40) | S1PR1ALDH1A1KDM4ESMN1; SMN2APP | |
| SCHEMBL14797044 | 0.78 | S1PR1 (0.52) | S1PR1ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL2228763 | 0.77 | S1PR1 (0.64) | S1PR1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL2225593 | 0.74 | S1PR1 (0.52) | S1PR1ALDH1A1KDM4EAPPHPGD | |
| SCHEMBL2225370 | 0.74 | S1PR1 (0.58) | S1PR1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL9932139 | 0.72 | SMN1; SMN2 (0.47) | KDM4ESMN1; SMN2HPGDMAOBMAPT | |
| SCHEMBL9931268 | 0.71 | PIK3CB (0.42) | ALDH1A1KDM4ESMN1; SMN2APPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729475-B1 | Carboxylic acid derivatives with an oxazolo[4,5-d]pyrimidine ring | SANOFI SA (FR) | 2015-06-10 | — | — | EP | disclosed |
| EP-2729475-B1 | Carboxylic acid derivatives with an oxazolo[4,5-d]pyrimidine ring | SANOFI SA (FR) | 2015-06-10 | — | — | EP | disclosed |
| US-9040544-B2 | 2,5-substituted oxazolopyrimidine derivatives | SANOFI (FR) | 2015-05-26 | — | — | US | disclosed |
| US-8846692-B2 | Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring | SANOFI (FR) | 2014-09-30 | — | — | US | disclosed |
| US-8846690-B2 | Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring | SANOFI (FR) | 2014-09-30 | — | — | US | disclosed |
| EP-2523963-B1 | 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES AS EDG-1 AGONISTS | SANOFI SA (FR) | 2014-08-27 | — | — | EP | disclosed |
| US-8735402-B2 | Cycloalkyloxycarboxylic acid derivatives | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| US-8735402-B2 | Cycloalkyloxycarboxylic acid derivatives | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| US-8735402-B2 | Cycloalkyloxycarboxylic acid derivatives | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-2729475-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[4,5-C]PYRIDINE RING | SANOFI (FR) | 2014-05-14 | — | — | EP | disclosed |
| US-20130023545-A1 | CYCLOALKYLOXYCARBOXYLIC ACID DERIVATIVES | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| US-20130023545-A1 | CYCLOALKYLOXYCARBOXYLIC ACID DERIVATIVES | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| WO-2013004828-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[4,5-C]PYRIDINE RING | SANOFI (FR) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013004828-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[4,5-C]PYRIDINE RING | SANOFI (FR) | 2013-01-10 | — | — | WO | disclosed |
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| EP-2523960-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| EP-2523963-A1 | 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086080-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011086081-A1 | 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023545-A1 | CYCLOALKYLOXYCARBOXYLIC ACID DERIVATIVES | C3AR1, CCR2, C5 | S1PR1 233/4885ALDH1A1 214/4885KDM4E 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.