Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224775 | 0.82 | S1PR1 (0.48) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL14486070 | 0.76 | PKM (0.34) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2224839 | 0.76 | PKM (0.34) | HPGDALDH1A1KDM4EL3MBTL1PKM | |
| SCHEMBL2146821 | 0.76 | PKM (0.34) | HPGDALDH1A1KDM4EL3MBTL1PKM | |
| SCHEMBL15966916 | 0.75 | MAOB (0.43) | HPGDALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL2228763 | 0.75 | S1PR1 (0.64) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2225593 | 0.72 | S1PR1 (0.52) | S1PR1HPGDALDH1A1KDM4ETP53 | |
| SCHEMBL14486171 | 0.72 | APP (0.44) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2225370 | 0.72 | S1PR1 (0.58) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL14486843 | 0.71 | SMN1; SMN2 (0.40) | S1PR1HPGDALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523959-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086078-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |