SCHEMBL22249164

SCHEMBL22249164

Nc1ccn(-c2ccc(CN3CC4CC(N)CC4C3)cc2)c(=O)n1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 5/20 0.47
BTK Q06187 1/20 0.35
HRH3 Q9Y5N1 2/20 0.33
ENPP2 Q13822 3/20 0.33
DPP4 P27487 2/20 0.32
DPP8 Q6V1X1 2/20 0.32
LIPE Q05469 1/20 0.32
HRH4 Q9H3N8 1/20 0.31
MCHR1 Q99705 1/20 0.31
JAK1 P23458 1/20 0.31
JAK3 P52333 1/20 0.31
CACNA1F O60840 2/20 0.31
LMNA P02545 2/20 0.31
ALB P02768 2/20 0.31
MAPT P10636 2/20 0.31
CACNA1D Q01668 2/20 0.31
CACNA1S Q13698 2/20 0.31
CACNA1C Q13936 2/20 0.31
PDE3A Q14432 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22254490 0.90 ROCK2 (0.49) ROCK2HRH3DPP4DPP8HRH4
SCHEMBL22248694 0.88 ROCK2 (0.49) ROCK2BTKHRH3DPP4DPP8
SCHEMBL22248366 0.86 ROCK2 (0.49) ROCK2HRH3LIPEMCHR1
SCHEMBL22248938 0.85 ROCK2 (0.48) ROCK2HRH3DPP4DPP8MCHR1
SCHEMBL22249157 0.85 ROCK2 (0.48) ROCK2HRH3DPP4DPP8MCHR1
SCHEMBL22248654 0.83 ROCK2 (0.50) ROCK2HRH3
SCHEMBL22254520 0.83 ROCK2 (0.48) ROCK2HRH3MCHR1JAK1JAK3
SCHEMBL22249176 0.83 ROCK2 (0.47) ROCK2BTKHRH3LIPEMCHR1
SCHEMBL22254826 0.83 ROCK2 (0.49) ROCK2BTKHRH3LIPEMCHR1
SCHEMBL22248937 0.82 ROCK2 (0.47) ROCK2HRH3HRH4MCHR1JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020150372-A1 ANTIMICROBIAL COMPOUNDS AND METHODS CURZA GLOBAL, LLC (US) 2020-07-23 WO disclosed