Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669322 | 0.90 | ALDH1A1 (0.33) | CYP2E1NR1I2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15015340 | 0.83 | RAB9A (0.42) | CYP2E1NR1I2RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14647676 | 0.82 | PIM1 (0.39) | CYP2E1NR1I2RAB9ASMN1; SMN2 | |
| SCHEMBL12518971 | 0.81 | NR1I2 (0.38) | CYP2E1NR1I2RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL12518984 | 0.81 | NR1I2 (0.38) | CYP2E1NR1I2RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL15015264 | 0.80 | CYP2E1 (0.42) | CYP2E1NR1I2 | |
| SCHEMBL12949303 | 0.80 | CYP2E1 (0.42) | CYP2E1NR1I2 | |
| SCHEMBL12444669 | 0.79 | RAF1 (0.34) | CYP2E1NR1I2RAB9ASMN1; SMN2 | |
| SCHEMBL12444667 | 0.79 | RAF1 (0.34) | CYP2E1NR1I2RAB9ASMN1; SMN2 | |
| SCHEMBL2218006 | 0.79 | RAF1 (0.34) | CYP2E1NR1I2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3219713-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2523950-B1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2523950-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088345-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-07-21 | — | — | WO | disclosed |