Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101864 | 0.82 | SCN9A (0.57) | NPC1RAB9AALDH1A1KMT2AHPGD | |
| SCHEMBL16598445 | 0.80 | HTT (0.66) | ALDH1A1SLC40A1MEN1KMT2AHPGD | |
| SCHEMBL16597986 | 0.77 | SMN1; SMN2 (0.67) | RAB9AALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL10095302 | 0.76 | VNN1 (0.62) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL29923875 | 0.75 | KMT2A (0.55) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL5090202 | 0.75 | HDAC3 (0.63) | KDM4CALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL19380018 | 0.74 | ALDH1A1 (0.59) | NPC1RAB9AKDM4CALDH1A1MAPT | |
| SCHEMBL28203957 | 0.74 | SCN9A (0.59) | NPC1RAB9AKDM4CALDH1A1MAPT | |
| SCHEMBL28463124 | 0.73 | POLB (0.62) | NPC1RAB9AKDM4CALDH1A1MAPT | |
| SCHEMBL1742676 | 0.73 | KDM4C (0.69) | NPC1RAB9AKDM4CALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |