Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236261 | 0.81 | ROCK2 (0.38) | POLBMAPT | |
| SCHEMBL5102502 | 0.78 | HTR1F (0.43) | JAK1JAK3JAK2TYK2HRH4 | |
| SCHEMBL5105549 | 0.78 | HTR1F (0.39) | JAK1JAK3JAK2TYK2KDM4E | |
| SCHEMBL5112753 | 0.78 | PDCD1 (0.39) | JAK1JAK3JAK2TYK2POLB | |
| SCHEMBL5111914 | 0.76 | BRPF1 (0.44) | KDM4EALDH1A1POLBMAPK1HSD17B10 | |
| SCHEMBL5103199 | 0.74 | CYP2C19 (0.38) | JAK1JAK3JAK2TYK2KDR | |
| SCHEMBL5106436 | 0.74 | ABL1 (0.43) | ALDH1A1POLBGAAKMT2ACYP2C19 | |
| SCHEMBL22235779 | 0.72 | GRIA1 (0.37) | JAK1JAK3JAK2TYK2KDR | |
| SCHEMBL5106326 | 0.70 | HTR1F (0.40) | JAK1JAK3KDM4EALDH1A1POLB | |
| SCHEMBL5106208 | 0.68 | ATR (0.38) | POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |