Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | IDO1 | P14902 | 10/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.42 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.42 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.42 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.42 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.42 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22275732 | 0.98 | LMNA (0.54) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| SCHEMBL11940573 | 0.83 | LMNA (0.47) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| SCHEMBL11940553 | 0.83 | LMNA (0.47) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| Bromide SCHEMBL2810146 | 0.78 | IDO1 (0.71) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| SCHEMBL20677857 | 0.78 | HTT (0.58) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| SCHEMBL2812696 | 0.76 | IDO1 (0.74) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| Bromide SCHEMBL4445136 | 0.74 | HTT (0.62) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| Bromide SCHEMBL22263142 | 0.74 | LMNA (0.43) | LMNAIDO1HTTSMN1; SMN2TAAR1 | |
| Bromide SCHEMBL22263095 | 0.74 | LMNA (0.43) | LMNAIDO1SMN1; SMN2HPGDNOS1 | |
| Hydrochloric Acid SCHEMBL22263112 | 0.74 | IDO1 (0.75) | LMNAIDO1HTTSMN1; SMN2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250092020-A1 | IDO/TDO Inhibitor | GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) | 2025-03-20 | — | — | US | disclosed |
| US-12209079-B2 | IDO/TDO inhibitor | GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) | 2025-01-28 | — | — | US | disclosed |
| US-20220380305-A1 | IDO/TDO Inhibitor | CANBAS CO., LTD. | 2022-12-01 | — | — | US | disclosed |
| US-20200239452-A1 | IDO/TDO Inhibitor | CANBAS CO., LTD. (JP) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12209079-B2 | IDO/TDO inhibitor | IDO1, IDO2, TDO2 | LMNA 4867/4885IDO1 1/4885HTT 71/4885 |
| US-20200239452-A1 | IDO/TDO Inhibitor | IDO1, IDO2, TDO2 | LMNA 4867/4885IDO1 1/4885HTT 71/4885 |
| US-20250092020-A1 | IDO/TDO Inhibitor | IDO1, IDO2, TDO2 | LMNA 4867/4885IDO1 1/4885HTT 71/4885 |
| US-20220380305-A1 | IDO/TDO Inhibitor | IDO1, IDO2, TDO2 | LMNA 4875/4885IDO1 1/4885HTT 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.