SCHEMBL22268474

SCHEMBL22268474

Cc1ccc(-c2ccc3c4ccccc4n(-c4cc(C#N)ccc4-c4nc(-c5ccccc5)cc(-c5ccccc5)n4)c3c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
ADORA2A P29274 2/20 0.41
ADORA1 P30542 2/20 0.41
PPARG P37231 1/20 0.41
NCOA2 Q15596 1/20 0.41
NCOA1 Q15788 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALDH1A3 P47895 2/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
AGTR1 P30556 1/20 0.36
ABCG2 Q9UNQ0 2/20 0.35
ABCB1 P08183 1/20 0.35
MYC P01106 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22268544 0.94 ABCG2 (0.40) KDM4EADORA2AMEN1KMT2AALDH1A3
SCHEMBL20114560 0.93 MEN1 (0.38) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL22268478 0.92 ADORA2A (0.37) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL20114689 0.90 PTGER4 (0.36) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL22268457 0.89 ABCG2 (0.40) KDM4EHPGDNPSR1MEN1KMT2A
SCHEMBL20114526 0.89 PTGER4 (0.37) MEN1KMT2AALDH1A3ALDH1A1ABCG2
SCHEMBL22268458 0.89 ALDH1A3 (0.38) KDM4EADORA2AADORA1MEN1KMT2A
SCHEMBL22268538 0.89 ABCG2 (0.43) KDM4EADORA2AADORA1MEN1KMT2A
SCHEMBL22563543 0.88 KDM4E (0.40) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL22268545 0.88 ABCG2 (0.40) KDM4EADORA2AMEN1KMT2AALDH1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392247-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-07-29 EP disclosed