Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694901 | 0.80 | AR (0.57) | XDHARALDH1A1HPGDKDM4E | |
| SCHEMBL11142880 | 0.79 | ALDH1A1 (0.61) | TRPV4ARALDH1A1KDM4EUSP2 | |
| SCHEMBL14117410 | 0.79 | XDH (0.43) | XDHARALDH1A1HPGDKDM4E | |
| SCHEMBL17101854 | 0.79 | KDM4E (0.66) | XDHARALDH1A1HPGDKDM4E | |
| SCHEMBL5901353 | 0.79 | XDH (0.46) | XDHARALDH1A1HPGDKDM4E | |
| SCHEMBL392560 | 0.79 | MAOB (0.47) | XDHARALDH1A1HPGDKMT2A | |
| SCHEMBL1197763 | 0.79 | MAPT (0.54) | XDHARALDH1A1HPGDKDM4E | |
| SCHEMBL11124624 | 0.79 | XDH (0.43) | TRPV4XDHARALDH1A1HPGD | |
| SCHEMBL13485290 | 0.79 | AR (0.49) | XDHARALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8516131 | 0.79 | XDH (0.46) | TRPV4XDHARALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002246-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2022-01-06 | — | — | US | disclosed |
| US-11149006-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | XWPharma Ltd. (KY) | 2021-10-19 | — | — | US | disclosed |
| US-20200239416-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002246-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | TACR1, KISS1R, TACR2 | TRPV4 697/4885XDH 3309/4885AR 3862/4885 |
| US-20200239416-A1 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF | TACR1, KISS1R, TACR2 | TRPV4 697/4885XDH 3309/4885AR 3862/4885 |
| US-11149006-B2 | Compounds as neurokinin-1 receptor antagonists and uses thereof | TACR1, KISS1R, TACR2 | TRPV4 697/4885XDH 3309/4885AR 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.