Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28296376 | 0.85 | NR3C1 (0.47) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL22273620 | 0.83 | NR3C1 (0.46) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL22273724 | 0.82 | RORC (0.46) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL22274052 | 0.81 | NR3C1 (0.44) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL29564093 | 0.79 | RORC (0.49) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL29563877 | 0.79 | RORC (0.42) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL29564114 | 0.79 | NR3C1 (0.45) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL22273613 | 0.79 | NR3C1 (0.45) | NR3C1PGRPOLBNR1I2MEN1 | |
| SCHEMBL22274053 | 0.78 | NR3C1 (0.42) | NR3C1PGRPOLBNR1I2KMT2A | |
| SCHEMBL28744878 | 0.77 | USP2 (0.55) | MEN1KMT2ARORCLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993576-B2 | N-benzyl-N-arylsulfonamide derivative and preparation and use thereof | HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2024-05-28 | — | — | US | disclosed |
| CN-109651297-B | N-benzyl-N-aryl sulfonamide derivative and preparation and application thereof | 杭州壹瑞医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |
| US-20220089555-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2022-03-24 | — | — | US | disclosed |
| EP-3915978-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | Hangzhou Yirui Pharmaceutical Technology Co., Ltd (CN) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020151687-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | 杭州壹瑞医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993576-B2 | N-benzyl-N-arylsulfonamide derivative and preparation and use thereof | KCNB1, KCNB2, KCNA3 | NR3C1 3111/4885PGR 4792/4885POLB 2947/4885 |
| US-20220089555-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | KCNB1, KCNB2, KCNA3 | NR3C1 3111/4885PGR 4792/4885POLB 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.