Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.55 |
| ▸ | TUBB | P07437 | 3/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280590 | 1.00 | LMNA (0.57) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL22280436 | 0.95 | ALDH1A1 (0.64) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL5769537 | 0.95 | ALDH1A1 (0.64) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL192613 | 0.95 | ALDH1A1 (0.64) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL4423384 | 0.94 | GPR119 (0.59) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL22280637 | 0.91 | HDAC4 (0.55) | ALDH1A1SMN1; SMN2MAPTGPR119HDAC4 | |
| SCHEMBL22280528 | 0.91 | HDAC4 (0.53) | LMNAHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL22280496 | 0.89 | HDAC4 (0.51) | LMNAHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL22280326 | 0.88 | HDAC4 (0.60) | ALDH1A1SMN1; SMN2MAPTGPR119HDAC4 | |
| SCHEMBL29523281 | 0.87 | HDAC4 (0.52) | LMNAALDH1A1SMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |