Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.48 |
| ▸ | TUBB | P07437 | 2/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280323 | 0.88 | NPC1 (0.66) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL22280324 | 0.88 | NPC1 (0.66) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL22280269 | 0.86 | RAB9A (0.71) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL22280325 | 0.86 | RAB9A (0.71) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL12188551 | 0.85 | NPC1 (0.85) | NPC1RAB9ALMNAHTTGRM5 | |
| Hydrochloric Acid SCHEMBL193440 | 0.85 | RAB9A (0.69) | NPC1RAB9ALMNAHTTGRM5 | |
| Hydrochloric Acid SCHEMBL193439 | 0.85 | RAB9A (0.69) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL4416033 | 0.85 | NPC1 (0.74) | NPC1RAB9ALMNAHTTGRM5 | |
| SCHEMBL25433735 | 0.84 | MAPT (0.54) | NPC1RAB9ALMNAHTTNR1H4 | |
| Hydrochloric Acid SCHEMBL7551864 | 0.84 | NPC1 (0.72) | NPC1RAB9ALMNAHTTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |